• HIV infection: seroconversion illness and during disease
progression
• Acute viral infections*
• Tuberculosis*
• Sarcoidosis*
• Corticosteroid therapy
• Purine metabolism defects; ADA and PNP deficiency
• SLE
* Reduce CD4 counts when not associated with HIV and can
further reduce levels in HIV infection. ADA, Adenosine
deaminase; PNP, Putine nucleoside phosphorylase
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