Wednesday, April 15, 2015

Why Post Cycle Therapy is Necessary Nolva

Bodybuilders and other athletes often take steroids to help with fat loss and to enhance muscle growth. But there are negative side effects to steroids. Once they stop taking the steroids there is the danger of experiencing a post cycle crash. Post cycle therapy or PCT is used to combat these negative side effects and avoid the crash. If you plan to take steroids you should plan your post cycle therapy in advance.

One of the reasons many people continue steroid use is because they suffered from a post cycle crash including muscle loss. To avoid this they would simply get back on steroids. But continued use of steroid use can cause problems. With the correct post cycle therapy you can stop steroid usage and not suffer as many negative side effects.

When you are using synthetic steroids your body is being given large amounts of testosterone. So much, that it stops producing its own testosterone or at the very least drastically slows production. Once you’re off your cycle your body will start producing testosterone again – but not right away.

Also, to combat the extra testosterone being produce while you’re on steroids, your body starts producing more estrogen. When you stop the steroids your body will still be producing the extra estrogen. This can cause unwanted side effects such as low sex drive, water retention and even breast production.

Because of these side effects; you want to get your hormones back into balance as quickly as possible. PCT helps get your body back into high gear. Without PCT, you can begin to lose the muscle mass you gained during your cycle.

PCT involves taking the following, HCG, Nolva and Clomid. These drugs help promote the production of testosterone until your body’s hormones are back in balance.

To reduce the amount of estrogen in your system, SERMS or Selective Estrogen Receptor Modulators are recommended. Two of the most popular are Clomiphene Citrate and Tamoxifen. These are usually started during the last few weeks of a steroid cycle and then continued for three or four weeks after.

PCT plans often include a cortisol suppressor. This is because anabolic steroids block the receptors in the muscles that normally take in cortisol. Your body will start producing more receptors to fight this. Without this your body can go into a catabolic state that depletes muscle tissue. This results in losing the muscle that you just gained during your cycle.

A good post cycle therapy plan will get your body back into hormonal balance as quickly as possible and reduce negative side effects. A forty-five day post cycle therapy is usually recommended. It’s important to also keep lifting weights and working out as you were before. This also helps prevent muscle loss.

You should also eat a healthy diet and be sure to get enough rest during your post therapy cycle. But for most users this is not enough to combat the side effects.

Tamoxifen Citrate (Nolva) is used to treat some types of breast cancer in men and women. It is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer. Since Tamoxifen Citrate (Nolva) has the ability of inhibiting the growth of tumors that respond to estrogens, it is one of the most popular drugs for treating node-positive breast cancer in women following total mastectomy or segmental mastectomy, axillary dissection, and breast irradiation. The antiestrogen is also recommended for treating metastatic breast cancer in women and men and Tamoxifen citrate is an alternative to oophorectomy or ovarian irradiation in premenopausal women with metastatic breast cancer. Medically, it is advised for the treatment of breast cancer that has spread to other parts of the body (metastatic breast cancer) and is also advised to treat breast cancer in certain patients after surgery and radiation therapy and may even be suggested to minimize the chances of breast cancer in high-risk patients.

One of the biggest advantages of this antiestrogen is that patients whose tumors are estrogen receptor positive are more likely to benefit from it. In addition to that, it can minimize the occurrence of contralateral breast cancer in patients receiving adjuvant therapy for breast cancer. In women with Ductal Carcinoma in Situ (DCIS) after breast surgery and radiation, Nolva can minimize the risk of invasive breast cancer. It is worthwhile to note that Tamoxifen Citrate is well tolerated in males with breast cancer and safety profile of the drug in males is similar to that noticed in women.

Sportsmen using anabolic steroids and performance enhancing drugs like Dianabol, Anadrol and Testosterone derivatives often make use of Nolvadex and medical studies in the past have suggested that use of this antiestrogen is associated with dramatic improvements in levels of luteinizing hormone, follicle-stimulating hormone, testosterone, and estrogen control.  Since use of Nolva is featured by its mild yet highly effective properties, it is often preferred compared to Arimidex, Femara, and Aromasin since it does not prevent aromatization but plays the role of an estrogen antagonist, which is also useful in burning fat.

The recommended dose of Tamoxifen Citrate (Nolva) for patients with Ductal Carcinoma in Situ (DCIS) is 20 mg daily for 5 years while sportsmen on steroids use it in doses of 20-45 mg per day, with or without food.

Nolva abuse can lead to side effects, which may be mild or severe, including hypercalcemia, peripheral edema, distaste for food, pruritus vulvae, depression, dizziness, light-headedness, headache, hair thinning and partial hair loss, and vaginal dryness. In very rare cases, side effects like erythema multiforme, Stevens-Johnson syndrome, bullous pemphigoid, interstitial pneumonitis, and rare reports of hypersensitivity reactions including angioedema may happen.

Women keen to use Tamoxifen citrate (Nolva) should avoid getting pregnant for two months after last stopping its use and others should best use birth control methods that don’t use hormones like diaphragms with spermicide or plain intrauterine devices (IUDs). Moreover, breast-feeding is not recommended while using this drug as it is unknown of Tamoxifen Citrate passes into breast milk or may cause potential risk to the infant. Nolva is not recommended to individuals suffering with high amount of calcium in the blood, severely decreased platelets, decreased white blood cells, cataracts, problems with eyesight, blood clot in lung, stroke, obstruction of a blood vessel by a blood clot, blood clot in a deep vein, pregnancy, or a mother who is producing milk and breastfeeding. A loss of sexual ability or interest may occur in men making use of Nolva.

Medical advice should be sought on an immediate basis after stopping use of Tamoxifen Citrate (Nolva) if side effects such as pain or pressure in pelvis, vaginal bleeding, changes in the amount or timing of bleeding or increased clotting, sudden chest pain, shortness of breath, coughing up blood, pain, tenderness, or swelling in one or both of your legs , sudden trouble seeing in one or both eyes, sudden severe headache with no known cause, sudden trouble walking, dizziness, loss of balance or coordination, or lack of appetite and yellowing of your skin or whites of eyes is noticed after making use of the anti estrogen.

Tuesday, April 7, 2015

Oxandrolone and HGH prevent HIV to improve performance

Chronic wasting syndrome, defined by a significant and unintentional weight loss, can occur in people with HIV/AIDS. There are many reasons why it happens including reactions to medications, lack of appetite, nausea, diarrhea and oral sores that make gaining or maintaining weight difficult. Whatever the cause, however, it's vitally important to help reverse the effects for the life of the patient.

People who suffer from chronic wasting often experience an increased progression of the infection and often a decrease in quality of life. Wasting is a form of malnutrition and it leaves the body more susceptible to the effects of the HIV/AIDS, infections and other complications because is can weaken the immune system. If left untreated it can often lead to a quicker death.

Often the first steps used to help reverse or at least stop the loss of lean body mass include nutritional programs, appetite stimulants and exercise programs. The problem is that they don't always work for HIV/AIDS patients. That's when HIV/AIDS patients and their physicians can turn to anabolic steroids for help.

Oxandrolone has been approved by the FDA to help counteract chronic wasting caused by other illnesses, so it's a logical leap to use it for AIDS-related chronic wasting as well. Right now, it's not a mainstream treatment because studies have shown that the most effective dosages for AIDS-related chronic wasting are higher than the FDA approved dosages, but it is beginning to show great benefits to its users.

Here's how anabolic steroids do the job needed to counteract the effects of wasting: One of the natural effects of anabolic steroids is its promotion of cell growth and tissues. People suffering from chronic wasting experience substantial loss of body tissues including both muscle and fat. When used properly, anabolic steroids can help increase the re-growth of muscle tissues and therefore, an overall increase in lean body mass.

Another effect of HIV/AIDS which is related to chronic wasting is lipodystrophy. Lipodystrophy is not necessarily a loss of weight, but rather a redistribution of fat in the body. Often what happens is that fat gathers at the back of the neck and around the abdomen and fat is often lost in the face, arms and legs. It can also lead to diabetes, hypertriglyceridemia and liver problems.

Anabolic steroids do not directly treat lipodystrophy. In fact, there aren't many treatment options for it. Steroids do, however, tend to help with the physical effects by reducing the fatty deposits caused by lipodystrophy.

Growth hormone therapy in adults:
The syndrome of adult growth hormone deficiency (AGHD) is characterized by abnormal fat and muscle mass composition, dyslipidemia, decreased bone mineral density, exercise capacity, and quality of life. AGHD can be a continuation of childhood GHD or result from hypothalamic or pituitary damage. An increase in mortality is seen in these patients attributed to cardiovascular risk factors. It is unclear if these risk factors are exclusively due to GHD or a result of reduced quality of life and sedentary lifestyle. Daily HGH injections to treat AGHD are associated with improvements in body composition, muscle strength, bone density, cardiovascular markers, and quality of life. Fluid retention is an adverse effect of GH therapy in adults and may cause symptoms of edema, carpal tunnel syndrome, arthralgias, and myalgias. Glucose intolerance and possibly Type 2 DM may also develop during treatment.

HIV-associated wasting is linked to alterations in the GH-IGF-1 axis and can be improved with GH treatment. HIV wasting is defined as unintentional loss of body weight and lean body mass in patients infected with HIV. Other treatments for HIV-associated wasting include testosterone and anabolic steroids which increase fat mass but not lean body mass. Increases in lean body mass correlate with improved survival. Clinical trials have shown improvements in weight, lean body mass, and decreases in fat mass when patients are treated for 12 weeks with HGH.

HGH is often abused in combination with anabolic steroids to increase muscle strength and athletic performance. The illicit use of androgen's is seen not only in athletes, but is now being used by a significant number of adults between the ages of 35 and 60 to get rid of love handles and build muscle as they try to stay young, as prescriptions for human growth hormone have become more frequent from "anti-aging" clinics. Adolescent boys feeling pressure from society to increase muscle mass and do better at sports are also increasing their use, and competitive athletes who might be tested for steroid use often turn to HGH to improve performance.

Friday, April 3, 2015

How to Stop Weight Loss While HIV Positive people

HIV-positive people often experience rapid weight loss, commonly referred to as wasting. Wasting happens to people both on and off HIV medications. People experiencing wasting can lose 5 to 10 percent or more of their total body weight in just six months. Not all of the weight lost is body fat. In fact, large portions of lost mass can come from tissue and muscle. Keep in mind that each person's body responds differently to HIV and some will still experience weight loss despite their best efforts to prevent it. Human immunodeficiency virus (HIV) causes acquired immunodeficiency syndrome (AIDS) by destroying CD4+ "helper T cells". In healthy individuals, helper T cells organize immune responses that protect the body from infection. When HIV invades the human system, it binds to co-receptors (typically CXCR4 or CCR5) on the surfaces of CD4+ cells and macrophages and introduces viral genetic material into these cells.

Once HIV has gained entry into the host cell, viral RNA is reverse transcribed into viral DNA and combines with the DNA of the host cell—so as the infected cell replicates, so, too, does the virus. Reverse transcription from viral RNA to viral DNA is a target for some antiviral drugs. As CD4+ cell levels become depleted with advancing HIV infection, viral replication within macrophages, dendritic cells and other cell types sustains viral load. HIV can be categorized based on its interaction with surface co-receptors during attachment and entry into host cells. Three primary entry methods comprise a large percentage of HIV cases – R5, which utilizes the receptor CCR5 to gain entry, X4, which uses the CXCR4 co-receptor, and X4R5, which uses both.

Given the dependency upon these cell-surface co-receptors for entry, some strains of HIV are unable to infect individuals who harbor mutations in the gene encoding the co-receptor. These people are resistant to the subtype(s) of HIV that would normally utilize a wild-type receptor to gain entry into host cells.

Make sure you're eating, at minimum, enough calories to maintain your weight. Also take into account additional calories you burn through exercise. Talk to your doctor about appetite-enhancing drugs that can counter the appetite-suppressing effects of many HIV medications. Try multiple small meals and snacks throughout the day if you have trouble finishing the regular three meals. Work with your doctor to find the right HIV medication regimen. Opt for one that controls your disease progression with the fewest side effects. HIV medications, and HIV itself, can cause diarrhea, vomiting, mouth sores and side effects that limit your ability to eat foods or absorb nutrients. Sometimes tweaking medications or adding new ones to your treatment plan can help with side effects.

Weight lift or do strength-training exercises at least two to three times per week. These activities will help build up muscle tissue and prevent muscle loss associated with wasting. Work each major muscle group, including your arms, legs, back, chest, shoulders and abdominal muscles. Never work the same muscle group two days in a row to help prevent muscle injury. Even lifting very small weights at home can help. Talk to a counselor or therapist about your feelings associated with your illness. HIV patients often experience depression, which can contribute to a loss of appetite or disinterest in taking good care of yourself. Work with your therapist to develop a treatment plan that may include medications, coping strategies, group therapy and support groups.
Consider prescription treatments that build up muscle strength and tissue. Ideal medications will also prevent muscle and tissue loss, according to the Tufts University School of Medicine. Treatments include steroids, testosterone injections and human growth hormone. Talk to your doctor to see if one or more of these treatments has benefits that outweigh their risks.

AIDS wasting, which leads to significant weight loss in people with HIV, causes severe loss of weight and muscle and can lead to muscle weakness, organ failure and shortened lifespan. Researchers have long sought to reverse this common, destructive effect of HIV with mixed success. The wasting stems from loss of the body’s ability to grow muscle and from low levels of testosterone. Anabolic steroids are synthetic substances similar to the male sex hormone testosterone that promote growth of skeletal muscle and the development of male sexual characteristics.

Although most recently in the news for their misuse by professional athletes, anabolic steroids have legitimate medical application for men with low testosterone and people with certain types of anemia. Two anabolic steroids available in the United States, Nandrolone Decanoate and Oxandrolone, have been used to help increase weight and muscle mass in small studies of people with wasting.  Conversely, anabolic steroid use has been associated with increased rates of HIV in those who share needles or use non sterile needles when they inject steroids.

In the review studies, anabolic steroids were administered to patients either orally or by injection. The main side effects were mild and included abnormal liver function tests; acne; mild increase in body hair; breast tenderness; increased libido, aggressiveness and irritability; and mood swings — all common side effect of anabolic steroid use. “The risks and side effects of taking anabolic steroids long-term are certainly of concern,” Johns said. “We were unable to assess these risks in our review due to the short duration of treatment in the studies.”

Wayne Dodge, the HIV/AIDS program director at the Group Health Cooperative in Seattle, suggests that clinicians should obtain blood testosterone levels, “if an HIV-infected individual has had significant weight loss, significant fatigue or muscle wasting, and particularly if associated with a significant decrease in libido and erections. If testosterone is in the low or low-normal range then a trial of steroids could be tried. The individual and the clinician should decide what result would constitute a successful trial: weight gain of 15 pounds, a 30 percent improvement in sense of well-being or a successful erection once a week.”

Thursday, March 26, 2015

Effect of Dianabol by Geneza Pharmaceuticals

Methandrostenolone is the chemical name for Dianabol. Dianabol (GP Methan) is known as literally the number one most popular and widely used anabolic steroid in existence, with the second most popular being Nandrolone Decanoate (Deca Durabolin), and third being Stanozolol (Winstrol). Dianabol (GP Methan) was also essentially the second anabolic steroid synthetically created, and is the first analogue of Testosterone to ever be developed (discounting Methyltestosterone, which is essentially orally active Testosterone).
The development of Dianabol (GP Methan) for all intents and purposes sparked the beginning of the anabolic steroid development boom, which began in the 1950s. With the Americans at a massive disadvantage, an investigation had been initiated into how the Soviet athletes were vastly superior, and various Soviet Olympic athletes that had defected to America had been studied. Shortly afterwards, it was discovered that these Soviet athletes had been administered supraphysiological amounts of Testosterone via intramuscular injection. It was this administration of Testosterone that was discovered to be a major changing factor in enhancing athletic ability, specifically in the areas of muscular strength.

Dianabol (also known as GP Methan, Dbol, Methandrostenolone, and methandienone) is one of the most popular anabolic steroids and performance enhancing drugs. This steroid is a very anabolic and androgenic drug that provides little progestational activity.

The chemical name of Dianabol (GP Methan) is [17a-methyl-17b-hydroxy-1,4-androstadien-3-one] and its molecular formula is C20H28O2. It has an anabolic-androgenic ratio of 90-210:40-60 and can be detected over a period of six weeks. It has the molecular weight of 300.44 g/mol at the base.

Categorized as a Schedule III drug under the Anabolic Steroid Control Act of 1990, Dianabol (GP Methan) is medically recommended to people suffering with osteoporosis and health complications requiring improved protein synthesis. The fact that 17α-methylation of the steroid helps it easily pass through the liver is one of the biggest reasons behind its popularity. Moreover, this steroid has the ability to minimize SHBG (sex hormone binding globulin), which deactivates steroids to prevent them from further reactions with the body. The drug is also suggested for treating health conditions like chronic adrenocortical insufficiency, thyrotoxicosis, interstitial-pituitary insufficiency, diabetic angiopathies (retinopathy and nephropathy), steroidal diabetes, and pituitary dwarfism. It can even be recommended during radiotherapy for laryngeal tumors.

The steroid has a profound effect on protein metabolism and promotes well being by facilitating positive nitrogen balance. Use of this steroid is also associated with improvement of mood, self-esteem, appetite, and self-confidence enhancements and normalizing effect on all functions of the body to promote physical and mental state and improving sleep patterns. In addition to that, the use of Dbol is linked to enhancements in terms of body calcium and potassium levels and offering assistance in the release of insulin besides transmission of sensor alerts. Dianabol is also admired by sportsmen as it its use for a period of six to eight weeks is related with glycogenolysis, nitrogen storage, protein synthesis, muscle mass, muscle function, and body strength gains that are nearly permanent. Dbol is commonly used by sportsmen to kick-start mass and strength gains at the start of a long bulking cycle. Since Dianabol (GP Methan) has a short active life, multiple doses of it are required to be taken throughout the day.

The recommended dose of Dbol for men is 25-50 mg per day when taken orally and 50-150 mg per week when taken in an injectable form. The anabolic compound is generally stacked with testosterone enanthate, Nandrolone, Anadrol, Proviron, Testosterone Propionate, Trenbolone acetate, and testosterone cypionate and post cycle therapy with antiestrogens such as Clomid and Nolvadex is highly recommended to restore production of naturally-occurring testosterone and reduce or eliminate estrogenic side effects.

This anabolic steroid is not recommended to girls and women, especially those who may get pregnant while using the steroid or already pregnant or lactating. Its use is also not recommended to children or those struggling with hypertension, high blood pressure, and prostate or breast cancer. Dbol should also not be used by people having an existing allergy to its ingredients. Use of Dianabol is not recommended to those suffering from health problems like testicular atrophy, testicular cancer, prostate cancer, breast cancer, liver damage, kidney damage, stroke, high blood pressure and respiratory problems.

Since Dbol can convert to estradiol via aromatase, estrogenic side effects may be a concern for users of this steroid. Some of the most common side effects of Dianabol include oily skin, acne, gynecomastia, water retention, and high blood pressure. In rare cases, nose bleeding may be a cause of concern while using Methandrostenolone. In order to avoid these side effects of Dbol, it is best to use an estrogen blocker such as Nolvadex or an aromatase inhibitor such as Arimidex. Being a 17-alpha-alkylated compound, Dbol (GP Methan) use can cause elevated liver values and therefore users of this anabolic steroid are advised to monitor liver function at regular intervals. Since liver toxicity may become a problem for some Dbol users, it is best to have ready supplies of Tyler Liver Detox or Milk Thistle. Moreover, users of the steroid should consume 7-9 glasses of water and take other liquids such as fresh juices at regular intervals or if the need arises. Dianabol use may cause side effects like increased aggression, male pattern baldness, clitoral hypertrophy, oily skin bouts, and insomnia and indiscriminate use of this steroid may lead to difficulty when urinating, edema (swelling), fever, or pain in the lower back (particularly in the kidney areas) and even high blood pressure and damage to kidneys. At no point of time, this anabolic steroid should be used in absence or contravention of medical advice. Moreover, use of Dianabol should always be made for a legal purpose and as per medical directions. In case a dose of the steroid is missed, for any reason, the same should be ignored and the next dose should be taken as scheduled.

Tuesday, March 17, 2015

Cytomel thyroid hormone for replacement therapy

Cytomel is not a steroid, but more a of a cutting aid. It's a synthetic form of the thyroid hormone tri-iodio-thyronine or T3, made up of a metabolite of the amino acid tyrosine and 3 iodine ions. In the body it in turn is made from another hormone, T4, which is secreted by the thyroid under influence of the pituitary hormone TSH (Thyroid stimulating hormone). If a shortage of either TSH or T4 is noted, usually doctors may opt for a replacement therapy. These days the most common prescription is synthetic T4 (Synthroid), but in more severe cases of permanent thyroid dysfunction, the choice is given to Cytomel. Simply because T4 is mostly active through its conversion to T3 and T3 is 4-5 times stronger than T4 on a mcg for mcg basis.

In bodybuilding circles Cytomel is mostly used as fat-loss drug. Thyroid hormones are often referred to as the metabolic regulators of the body. High levels of T3 speed up the metabolism of an individual, allowing him to burn more calories and use calories more sufficiently. Generally ectopmorphic body-types have very high thyroid levels and in some cases a slight undiagnosed form of hyperthyroidism. Both hyper-and hypothyroidism can have severe consequences on an individual, such as goiters and other nasty stuff, so messing with your thyroid is not something. As with insulin, misuse of this compound can leave you dependent on exogenous T3 for the rest of your life. So some caution and research is required before putting Cytomel in your body. Generally cycles should be limited to 4-6 weeks tops,  recommend 3 and alternating cycles with 3-week cycles of Clenbuterol. But most importantly, to avoid a crash or a shock to the thyroid function doses need to be built up over time and tapered off again. More so for Cytomel than for any other drug in existence.

Cytomel is not a drug to start off on, and that use of milder drugs like T4 (Synthroid) or triacana can help ease a person into the use of T3. T4 is basically similar to Cytomel except that its weaker. Something that users normally compensate with higher doses and sends them down a similar lane as simply using Cytomel. Agreed, Cytomel is NOT a drug for beginners, but with adequate research, experience with diet and some self-control, why cytomel shouldn't be the first thyoid compound used. But for recreational users looking for a fatburner. Cytomel is much more powerful, but Clenbuterol is a lot safer for use. The results are easier to maintain with clenbuterol as well. Negative feedback in the thyroid may decrease natural levels of T3 in the body, causing a decrease of metabolic rate after coming off a cycle of T3. That can cause a rebound effect during which a lot of weight is gained back.

 Cytomel is the popularly recognized brand name for the drug Liothyronine Sodium. This is not an anabolic steroid but a thyroid hormone. It is used medically to treat cases of thyroid insufficiency, obesity, certain metabolic disorders and fatigue. Specifically this drug is a pharmaceutical preparation of the natural thyroid hormone triiodothyronine (T-3). When administered, Cytomel increases the patient's metabolism. The result is an increased rate of cellular activity (noted by a more rapid utilization of carbohydrates, fats and proteins). Bodybuilders are particularly attracted to this drug for its ability to burn off body excess fat. Most often utilized during contest preparation, one can greatly decrease the amount of stored fat without being forced to severely restrict calories. To this end Cytomel is commonly used in conjunction with Clenbuterol and can produce extremely dramatic results. This combination has become very popular in recent years, no doubt responsible for many "ripped" on-stage physiques. It is also noted by many that when thyroid hormones are taken in conjunction with steroids, an increased anabolic effect can be seen (noticeably greater than if the steroids are used alone). This is likely due to faster utilization of proteins by the body, increasing the rate for new muscle accumulation.

One should take caution if considering using this drug. Cytomel comes with an extensive list of warnings and precautions which are not to be ignored. Side effects include, but are not limited to, heart palpitations, agitation, shortness of breath, irregular heartbeat, sweating, nausea, headaches, and psychic/metabolic disorders. It is a powerful hormone, and one that could potentially alter the normal functioning of the body if misused. When administering Cytomel, one must remember to increase the dosage slowly. Generally one 25mcg tablet is taken on the first day, and the dosage is thereafter increased by one tablet every three of four days for a maximum dosage of 100mcg. This will help the body adjust to the increased thyroid hormone, hopefully avoiding any sudden "shock" to the system. The daily dose is also to be split evenly throughout the day, in an effort to keep blood levels steadier. Women are more sensitive to the side effects of Cytomel than men, and usually opt to take no more than 50mcg daily.

It is important to stress that a cycle should last no longer than 6 weeks and it should never be halted abruptly. As slowly as the dosage was built up it should also be lowered, one tablet every 3-4 days. Taking Cytomel for too long and/or at too high a dosage can result in a permanent thyroid deficiency. After doing such, one might need to be treated with a drug like Cytomel for life. It is also a good idea to first consult your physician and have your thyroid function tested. An undiagnosed hyper function would not mix well with the added hormone. An athlete should also be sure never to purchase an injectable form of the drug. It is generally an emergency room product, much too powerful for athletic use. Since T-3 is the most powerful thyroid hormone athletes are using, this is generally not the starting point for a beginner. Before using such a powerful item, it is a good idea to become familiar with a weaker substance. An in-between point is Synthroid (Synthetic T-4), still weaker in action than Cytomel. Once the user is ready however, the fat burning effect of this hormone can be extremely dramatic.

Thursday, March 12, 2015

Benefits of GP Methan by Geneza Pharmaceuticals


GP Methan by Geneza Pharmaceuticals was more or less the second anabolic steroid ever produced. The first, as we all know was Testosterone, which was produced in the early 1900s and experimented with by Nazis in WW2, in an attempt to produce a better soldier. Enough with the history lesson, lets get into what this GP Methan is and what it does. Well, first off, its usually found in pill form, though it can be found as an injectable also (Under the Trade name: Reforvit-B, which is 25mgs of methandrostenolone mixed with B-vitamins). GP Methan is a 17aa steroid, which means it has been altered at the 17th Carbon position, to survive its first pass through your liver, and make it into your blood stream. GP Methan will raise your blood pressure and is also hepatoxic (Liver-Toxic), so be careful with it. Lets examine this particular study a bit further, though:

GP Methan this study, done in the early 80s, a very high dose of Dianabol (100mgs/day for 6 weeks) decreased plasma testosterone to about 40% of its normal value, plasma GH went up about a third, LH dropped to about 80% of its original value, and FSH went down about a third also (these are all approximate numbers, for the sake of brevity, but you get the idea). Body fat did not go up significantly and fat free mass went up anywhere between 2-7kgs (3.3kgs average gain). The researchers concluded that GP Methan increases Fat Free Mass as well as increasing strength and performance.

Side effects:
As with many other 17aa steroids, GP Methan is also a very weak binder to the androgen receptor, so most of its effects are thought to be non-receptor mediated, and are attributable to other mechanisms (i.e. protein synthesis as indicated by the production of muscle tissue with very high levels of nitrogen, etc. which was indicated in the 100mg/day study). This also means GP Methan only has a modest aromatase activity.

In order to kick start a Dianabol cycle, usually what you do is incorporate a fast acting oral like GP Methan (or anadrol) and combine it with long acting injectables (such as Deca or Equipoise with some Testosterone). The reasoning here is that the oral will give almost immediate results, while the injectable takes time to produce results. The end result is that you start seeing results within the first week of your cycle and continue up until the end with the injectables. This entails taking anywhere from 25-50mgs of dbol (although as little as 20mgs or as much as 100mgs have been reported) for 3-6 weeks at the start of a cycle (average time for a "Kick Start" is 4 weeks, though), and then ceasing their use as the injectables start to produce results.

In order to successfully bridge between cycles (and this means using a low dose of anabolic steroids, in this case dbol), you need to recover your natural hormonal levels to pre-cycle levels or to within acceptable parameters, and then you start your next cycle. The idea here is that you wont lose any gains, but rather a low dose of an anabolic steroids will help you maintain them. Typically, you'd use around 10mgs/day of dbol and combine it with an aggressive Post-Cycle Therapy (PCT) course of Nolvadex (and/or Clomid) and HCG. This would give you full androgen replacement from the GP Methan and a shot at recovering your natural hormonal levels via the other stuff you are taking. Remember, the 100mg/day dose of dbol in the study we looked at earlier did not suppress Test, LH, or FSH to a degree that would make recovery impossible and certainly not with 1/10th that dose in conjunction with an aggressive PCT.

Friday, March 6, 2015

How to take Nolvadex, HCG and Clomid for PCT

Post-cycle treatment (PCT) is often overlooked as just another nuisance, but in fact it is a very important aspect of a steroid cycle. In men, anabolic steroid administration produces a predictable, dose-dependent depression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), via the negative feedback loop of the hypothalamic-pituitary-gonadal axis (HPGA/HPTA).  There is no point in spending your money on steroids and many hours in the gym just to lose it all at the end of a cycle because you didn’t recover your endogenous hormone production afterwards. PCT with chorionic gonadotropin (hCG) and anti-estrogen drugs will speed-up recovery by stimulating LH production.


How To Take Clomid:
Clomid has a long half-life (possibly 5 days), so there is no need to split up doses throughout the day. If Sustanon has been used and Clomid is commenced 3 weeks after the last injection, I would estimate that androgen levels are low enough to start sending the correct signals. If androgen levels are still a little high, we need to start at a high enough amount that will work or help, even if androgen levels are still a little high. Try 300mg on day 1, then use 100mg for the next 10 days, followed by 50mg for 10 days.

How to take Nolvadex for PCT:

As an alternative to Clomid, which has been reported to have led to unwanted side effects such as visual disturbances in some users, Nolvadex can be employed. Nolvadex is a trade name for the drug Tamoxifen. Like Clomid, the half life of Nolvadex is relatively long enabling the user to implement a single daily dosing schedule. Administration would start as per the timescales outlined above and the duration would be identical to that of Clomid.

Typically, for a moderate-heavy cycle, the following dosages would be used:
Day 1 - 100mg
Following 10 days - 60mg
Following 10 days - 40mg

Occasionally, heavier cycles containing perhaps Nandrolone (Deca) or Trenbolone which by definition are particularly suppressive of the HPTA, may require a slightly longer therapy. Likewise, more modest/shorter cycles may require lower dosages, perhaps dropping each by 20mg per day.

Some users like to use both Clomid and Nolvadex in their PCT in an attempt to cover all angles. An example of the dosages involved might be:
Day 1 - Clomid 200mg + Nolvadex 40mg
Following 10 days - Clomid 50mg + Nolvadex 20mg
Following 10 days - Clomid 50mg or Nolvadex 20mg

Of course, the examples provided are not set in stone and may be adjusted

Using HCG:
HCG stands for Human Chorionic Gonadotrophin and is not a steroid, but a natural peptide hormone which develops in the placenta of pregnant women during pregnancy to controls the mother's hormones. (Incidentally, this is the reason you may hear of people testing for growth hormone (HGH) with a pregnancy testing kit - If their HGH shows "pregnant".

Its action in the male body is like that of LH, stimulating the Leydig cells in the testes to produce testosterone even in the absence of endogenous LH. HCG is therefore used during longer or heavier steroid cycles to maintain testicular size and condition, or to bring atrophied (shrunken) testicles back up to their original condition in preparation for post-cycle Clomid therapy. This process is necessary because atrophied testicles produce reduced levels of natural testosterone, this situation should be rectified prior to post-cycle Clomid therapy.

HCG administration post-cycle is common practice among bodybuilders in the belief that it will aid the natural testosterone recovery, but this theory is unfounded and also counterproductive. The rapid rise in both testosterone, and thus oestrogen due to aromatisation, from the administration of HCG causes further inhibition of the HPTA (Hypothalamic/Pituitary/Testicular Axis - feedback loop discussed above), this actually worsens the recovery situation. HCG does not restore the natural testosterone production.

The typically observed dosing of 2000 to 5000IU every 4 to 5 days causes such an increase in oestrogen levels via aromatisation of the natural testosterone that this has been responsible for many cases of gynecomastia.

From the above discussion it is clear that HCG is best used during a cycle, either to:
1) Avoid testicular atrophy, or
2) Rectify the problem of an existing testicular atrophy.

HCG Dosage:

Smaller doses, more frequently during a cycle will give best overall results with least unwanted side effects. Somewhere between 500IU and 1000IU per day would be best over about a two-week period. These doses are sufficient to avoid/rectify testicular atrophy without increasing oestrogen levels too dramatically and risking gynecomastia. This dosing schedule also avoids the risk of permanently down-regulating the LH receptors in the testes.

It is important for the HCG administration to have been completed with 6 or 7 clear days before the onset of PCT in order to avoid inhibition of the Nolvadex and Clomid therapy. Also, a small daily dose (10-20mg) of Nolvadex would normally be used in conjunction with HCG in order to prevent oestrogenic symptoms caused by sudden increases in aromatisation.

Synthetic HCG is often known as Pregnyl (generic name) and is available in 2500iu and 5000iu (not ideal for the above doses!). Administration of the compound is either by intra-muscular or subcutaneous injection. It comes as a powder which needs to be mixed with the sterile water. The powder is temperature-sensitive prior to mixing and should not be exposed to direct heat. After mixing, it should be kept refrigerated and used within a few weeks - though there are sterility issues which need to be considered after mixing.
Clomid and/or Nolvadex are more effective than HCG post cycle, but some long-term users like to use HCG during a cycle, or to prepare the testes for Clomid and Nolvadex therapy.
For example, if Dianabol, Sustanon and Winstrol were cycled, the time for administering Clomid should be 3 weeks post cycle, as Sustanon remains active in the body for the longest period of time.

Clomid is available in 50mg tablets most commonly, but also comes in 25mg capsule, often in boxes of 24 tablets. Tamoxifen is made by a number of manufacturers and comes in 10mg or 20mg tablets, most commonly 30 x 20mg tablets. HCG generally comes in kits of three ampoules of powder needing to be mixed with the provided injectable water as 1500IU, 2500IU or 5000IU per ampoule kits.

depending on the factors outlined above and individual variances.

Tuesday, February 24, 2015

How use Testosterone Enanthate or Primoteston in sports


Steroids were once viewed as a substance only being used by body builders, fitness fanatics and professional athletes, however, in the society of today, steroid use is becoming more commonplace. Testosterone is an anabolic steroid secreted by the testicles in a male, in the ovaries of women and in small amounts by the adrenal glands in both sexes.  In males, testosterone plays an integral role in overall health and accounts for the physical differences between genders.

For males, testosterone is responsible for virilization and androgenic qualities.  The anabolic effects of testosterone include muscle growth and strength, increase in bone density and stimulating linear growth and bone maturation.  The virilizing effects of testosterone in males includes maturation of the sex organs, deepening of the voice, the growth of facial hair and male secondary sexual characteristics.

How testosterone effects the female body is best witnessed in adulthood.  The hormone is responsible for clitoral enlargement, sex drive, mental and physical energy and plays a role in the fight-or-flight hormonal response regulation.

Testosterone can be labeled as the “impulse” hormone, and how it effects the body of a male versus a female differs dramatically.  Having a normal level of testosterone in the body is very important for the health, development and well-being of both males and females.

How Testosterone Builds Muscle:
There are many hormones that play an important part of how the body responds to exercise, increases strength and builds muscle tissue.  Testosterone is an anabolic steroidal hormone, the word “anabolic,” refers to the building up of body tissues.

Testosterone is the number one hormone used in the development of muscle and strength and through regular exercise, fine motor skills, fitness, muscle and bone strength and joint function increase.  The mechanism of action by which testosterone increases muscle mass is not well documented and further studies are ongoing.

Primotestone (Testosterone Enanthate) is an injectable steroid which first developed in the 1950s. Primoteston has a slow release mechanism allowing less frequent injections while the steroid remains active for between 2 and 3 weeks. Replacing Oreton (testosterone propionate), Primoteston has generally been used in the medical community for the treatment of delayed puberty as well as in androgen deficient patients. Testosterone Enanthate compounds have also been shown to be an effective male contraceptive, but it has not achieved popularity in this regard. Despite its age and unsophistication, especially when compared to newer products on the market, still remains one of the top bulking choices, particularly in the U.S., amongst those seeking performance enhancements. In fact, enanthate is the most popular ester of testosterone currently available.

Primoteston Effects: Like all testosterone based steroids, Primoteston aromatizes into estrogen which results in significant water retention. Although this artificially raises weight and hides muscles gains. It does, however, protects the muscles and the joints while the testosterone promotes muscle growth. These side effects can be mitigated with the use of an anti-estrogen but are generally only necessary when higher dosages are being administered. Gains with Testosterone Enanthate based compounds such as Primoteston are significant.

Because the body only naturally produces between 2.5 and 11 mg of testosterone per day, one can easily imagine the effects increasing that amount significantly could have. Primoteston functions by promoting nitrogen retention within the muscles which, in turn, allows more protein to be stored supporting more rapid tissue growth. It also increases production IGF-1, a naturally occurring anabolic in the body. Red blood cell levels should also increase while on Primoteston. This results in a higher VO2 max is possible. It also boosts recovery times, energy, and libido. Testosterone enanthate based compounds such as Primoteston are generally used for bulking although it can be effective while cutting provided the user is on a strict diet. Women are advised against using Primoteston due to its masculanizing effects.

Primoteston Dosage and Side Effects: Within the bodybuilding community, the standard injection dose is usually between 200 and 600mg once or twice weekly for 6-12 weeks. Higher doses than those specified are not uncommon with advanced bodybuilders but side effects will become much more pronounced as the dose is increased. Testosterone Enanthate compounds are also stackable and combines well with other steroids. As mentioned above, female body builders are advised against using Primoteston as it is difficult to maintain hormone levels and prevent virilization.

Side effects of Primoteston may include an increase in estrogen levels (resulting in gynecomastia at higher levels), water retention, body hair growth, acne, oily skin, testosterone suppression, increased aggression, male pattern hair loss, negatively affected cholesterol levels and a rise in blood pressure (albeit a significantly lower rise than with other steroids). Men who are predisposed to hair loss may wish to consider a less androgenic steroid. Many of these side effects can be effectively minimized, controlled and potentially avoided with proper supplements. Testosterone levels should return to their natural levels within approximately 1-4 months without any intervention or post-cycle therapy. Women, who are not recommended to take Testosterone based compounds, will be at risk of masculinization related effects. These consist of a deepening in their voice, body and facial hair growth, menstrual irregularities, and clitoral enlargement. In the event any of the aforementioned symptoms begin to manifest, women should cease use immediately to avoid permanent changes. Athletes using Primoteston are advised to use a step down routine after ending a cycle in order to reduce the possibility of a post-cycle crash. This may not be necessary for cycles less than 10 weeks.

Thursday, February 19, 2015

Very powerful oral steroid GP Oxy

Anapolon (GP Oxy) is a very powerful oral steroid. It is considered by many bodybuilders to be the ultimate mass building drug. This remarkable ability to increase muscle mass comes at a price though and the main drawback of this steroid is the number and severity of side-effects associated with it. Just about every side-effect linked to steroid use is likely to be experienced while using this drug. The most severe in my opinion is Anapolon’s toxic effects on the liver. However, one has to take into account the dosage range for this drug. Anapolon is taken in dosages between 50 to 150mg per day, where many others like Dianabol and Winstrol are taken in dosages from 10 to 40mg per day. This makes a direct comparison impossible and it’s very likely that 150mg of Winstrol will be just as toxic if not more harmful.

The most common daily dose of Anapolon (GP Oxy) is 100mg, but even at that dosage side-effects like water-retention, elevated blood pressure, acne, hair loss, blood clotting changes, gynocomastia, liver toxicity and mood swings are very often reported. Using aromatase inhibitors to control estrogen aromatization will be ineffective as this drug does not directly convert into estrogen. It was suggested that oxymetholone can activate the estrogen receptor, similar to, but more profoundly than the estrogenic androgen methandriol. Supplements like Milk Thistle can be taken to help keep liver enzyme levels between safe ranges.

When used correctly and responsibly Anapolon (GP Oxy) makes a great addition to any bulking cycle. The best results are seen when Anapolon is stacked in conjunction with other injectable steroids. Anapolon makes a great kickstart to a bulking cycle and is normally used during the first 3 to 4 weeks of the cycle. Avoid using other oral steroids in the same stack, because when combined with other 17-alpha alkylated compounds the hepatotoxic effects will become impossible to control and serious liver damage may occur.

A dosage of 1-2mg per kilogram of body weight is a good starting place, however not recommend this drug to novice steroid users and they are better off looking into Dianabol as a kick start. A drop in weight is often experienced when the switch is made from the kick start phase to the remainder of the cycle, but this is likely to be water weight only and should not be of any concern.  It was designed to be a safe and mind anabolic steroid and in low doses was well tolerated by women and children. Oxandrolone is a Class I anabolic, mildly androgenic steroid, which makes it safe to use in many cases. This drug has been used for anything from, burn victims to treatment of osteoporosis as it provides calcium to the body which will aid in bone regeneration. However in 1989 this drug was discontinued by Searle Laboratories partly due to the illegal use among bodybuilders. Around 6 years later Bio-Technology General Corp negotiated a deal with Searle where they would continue to manufacture the drug Anavar and supply it to BTG. This is when a press release went out stating its effects on involuntary weight loss and focused itself on HIV/AID’s wasting indications which were approved by the FDA where they were able to dictate the price by it being granted Orphan Drug status by the Food and Drug Administration.

As stated in the history of Anavar it is a Class I anabolic steroid giving it mild anabolic and low androgenic properties. This drug is also a derivative of dihydrotestosterone (DHT) and this is where confusion comes into its effects. Due to it being a derivate of DHT this drug is already “5-alpha reduced”, meaning it is unable to react with this enzyme like the means of testosterone making it a more potent form of “di hydro”. There is no conversion from neurosteroid allopregnanolone (5AR type I) to DHT(5AR type II), so false claims of using Procepia (Finasteride) which inhibits 5AR type II or Dutasteride which inhibits both 5AR type I and type II would be completely ineffective. However if you are concerned about hair loss there have been reports that spironolactone, flutamide and nizorol shampoo may work.

Now that we have that out the way let’s talk about some of the positive effects and dosing of this drug. Dosage of Anavar for men is in the region of 40 to 100mg every day. The active life of this drug is around 9 hours so splitting your dose up during the day would be advised.

Anavar starts to work within minutes of digestion however people reported noticeable changes from day 3 where they reported larger pumps. As far as strength and vascularity this happens anywhere from day 8 to 14 of the cycle, the strength on this product is insane and increases every week. It is reported that Oxandrolone causes a strong strength gain by stimulating the phosphocreatine synthesis in the muscle cell without depositing water and I’m guessing this is why reports state adding creatine to your Anavar cycle could be favoured. Anavar has also being closed linked to fat loss, and in a study there were reports of reduction in abdominal and visceral fat in men, the other logical explanation is its appetite suppressant effects.

Anavar is pretty mild on the liver and even though it is a 17aa compound, meaning that it´s been altered to first pass through your liver without being destroyed, however Anavar is not primary metabolized by the liver like other 17-alpha alkylated orals. At higher doses however one can see an increase in liver enzyme values, these results return to normal after cessation of a moderate, short cycle.

As much as many researchers might claim that Anavar doesn’t supress your Hypothalamic-pituitary-gonadal axis (HPTA) it does. Research has shown a dose as low as 2.5mg a day can supress some. And because this product is suppressive, proper post cycle therapy (PCT) is a must. However a minimum of Clomid / Nolvadex would be required however Human Chorionic Gonadotropin or a synthetic version like Ovidrel would be desired. Dosage plays a large part in the effects this drug will have on your HPTA and sex drive and anywhere on the 40mg mark could tip either way.

Wednesday, February 11, 2015

Sustanon and Testosterone replacement therapy

Testosterone plays a big role in creating and maintaining the levels of supremacy, status, and power. This is not just because the primary male sex hormone is one of the biggest factors driving competitiveness in men, but also because it encourages men to gain and maintain power and amp; social status. However, some men may face deficiency of testosterone (low testosterone, low T, hypogonadism or andropause) as they age.

Low testosterone levels in men are characterized by signs and symptoms such as reduced sex drive, sperm production, bone density, red blood cell production, muscle mass, fat distribution, lethargy, energy levels, and body strength. A fall in testosterone would therefore mean weak bones, low energy, significant physical and emotional changes, increased fat tissue, increased risk of osteoporosis, constant fatigue, depression, and increased risk of Alzheimer’s disease and erectile dysfunction.

In today’s highly competitive world where second chances are rare to come by, the pressure to win at all costs surely leaves us left with stress and sedentary lifestyles. These are the times when the body takes a huge toll and the production of natural hormones such as Testosterone start declining at a gradual and speedy pace. This means we not only face an increased risk of memory, concentration, libido, and energy loss, but our body’s ability to produce sperm and maintain bone density is hampered. This is where a potent drug like Sustanon 250 comes into the picture.

Prescribed medically for replacement therapy, Sustanon is a blend of four compounds of testosterone: 30 mg Testosterone Propionate, 60 mg testosterone phenylpropionate, 60 mg testosterone Isocaproate, and 100 mg testosterone decanoate. This anabolic androgenic steroid is prescribed worldwide for men diagnosed with low testosterone levels. This oil-based injectable blend has the chemical name of 17ß-hydroxyandrost-4-en-3-one and can be detected over a period of 2-3 months. This drug, prescribed as part of replacement therapy, is ideally used in doses of 250-500mg every week by men though some men tend to administer this steroid in weekly doses of 1000-2000mg. Athletes and bodybuilders stack this steroid with anabolic androgenic steroids such as Trenbolone, Anadrol, Winstrol, Dianabol, Masteron and Parabolan. However, Sustanon should be used with great care and diligence. This drug is not recommended to girls and women, especially if pregnant or breastfeeding or those who may get pregnant while using this drug.

Extremely popular among those in strength athletics and bodybuilding, Sustanon is one steroid that can always and easily be associated with promoting the sense of well being. Use of this steroid improves libido and erectile function and stimulates improvements in levels of hemoglobin and Hematocrit without any clinically relevant changes in liver enzymes and PSA. Moreover, Sustanon use is characterized by low fat deposition and water retention levels that make muscles appear smooth, strong, and ripped. The list of benefits associated with this potent and affordable steroid does not end here. Sustanon use for a period of eight to twelve weeks is also linked with improved reflexes and invincibility and this steroid can even improve the number of motor neurons in skeletal muscles and enhance neuromuscular transmission.

Ttestosterone replacement therapy with sustanon has the potential of improving the signs and symptoms of low testosterone in men diagnosed with Hypogonadism, a health condition in which the male body is unable to produce sufficient amounts of testosterone because of a problem with the testicles or with the pituitary gland controlling the testicles. It is for these and many more reasons that Sustanon is rated very highly by medical practitioners across the world to treat men with fewer spontaneous erections, reduced sexual desire, sleep disturbances, increased body fat, reduced muscle bulk, or decreased bone density. Use of this anabolic androgenic steroid is also associated with dramatic improvements in the levels of PSA, hemoglobin, hematocrit, lipid profiles, and liver function tests. Moreover, improved testosterone levels also prove useful in reducing body fat as the primary male sex hormone plays a critical role in regulating insulin, fat metabolism, and glucose. If that was not all, improved testosterone also results in improved muscle mass and body strength by increasing protein synthesis besides stimulating the drive to win and the desires for power and status.

Side effects:
Side-effects from using Sustanon 250 are consistent with side-effects of any testosterone. They include water retention and gynecomastia (bitch tits) from testosterone’s conversion to estrogen by the aromatase enzyme. Users on Sustanon also risk side-effects like hair loss and swelling of the prostate, mainly from testosterone’s conversion to dihydrotestosterone (DHT) by the 5-reductase enzyme. Both of these side-effects can be minimized with the use of selective estrogen receptor modulators (SERMs) like nolvadex (tamoxifen) or aromatase inhibitors (AIs) like aromasin.

Higher levels of testosterone also cause more oil to be secreted on the skin; thus, increasing your chances of getting acne. In addition, you will be more prone to sweating and your urine will have a “solvent-like” smell if you exceed 500-750mgs of sust per week.


Best Sustanon Cycles For Male Athletes:

Friday, February 6, 2015

The best steroids in the history of bodybuilding Nandrolone Decanoate

Nandrolone is one of the best known steroids in the history of bodybuilding. Originally synthesized in 1950s, athletes quickly found there was a good use for this powerful steroid. As far back as the mid 1960's Nandrolone has been used as a great addition to a dianabol and/or testosterone cycle. Since Nandrolone works for any athlete looking to increase the amount of steroids he is using, without increasing the side effects, it has been a favorite of many old school bodybuilders. In simple terms, deca allows you to use more steroids, without having more side effects.

Interestingly, trace amounts of Nandrolone have been found in the urine of pregnant women after the 6th week; as a result, we know that it is possible for a human body to make base Nandrolone. 

Nandrolone is the base hormone, but it is better known under the trade name Deca Durabolin, which contains Nandrolone Decanoate. This popular preparation takes the nandrolone hormone and adds a decanoate ester chain. This ester chain is attached during the manufacturing process and it serves dual purposes. The main purpose is to make the hormone oil soluble, so it can be put in an amp or multi-dose vial. The second purpose of this ester chain is to slow-release the steroid by keeping deca from interacting with androgen receptors until the ester chain is cleaved off by enzymes in your body. Since Nandrolone Decanoate cannot attach to an androgen receptor until enzymes in your body have cleaved off the decanoate ester, it causes the steroid to slow-release into your system over many days. For medical use, the ester's main function is to allow the hormone to be injected only once every 3 weeks. However, bodybuilders may inject Deca Durabolin weekly or as often as every three days.

Since the mid 1960's, Deca Durabolion has become a staple in most testosterone and/or dianabol cycles, the main reason is that Deca adds a lot of strength to a cycle without increasing side effects.

When used in a testosterone and/or dianabol cycle, deca really adds weight to the cycle without much more stress on the system. Deca does not add additional side-effects when used with other steroids, but it should never be used alone. Standalone use of Nandrolone comes with its very own set of nasty side-effects, the most infamous of them all, where the affected user is unable to get or sustain an erection. This is due to the fact that without the stronger testosterone metabolites like dihydrotestosterone (DHT), the softer and much weaker metabolites from deca will flood your receptors, not leaving room for stronger androgens. Not only are deca's weaker metabolites an issue when there is an absence of stronger androngens, but nandrolone itself can, and will, attach to progesterone receptors. This causes side effects that only affect the user in the absence of supraphysiological amounts of stronger androgens.

The best way to explain Deca Durabolin is that it's basically a progesterone-like hormone that builds muscle mass, strength and, to a lesser degree, helps repair joints. It should not give you any bad side effects when used with stronger androgens that will mask and counteract possible problems from Nandrolone. If ever used by itself, the bad side-effects from Nandrolone will crush your libido, sexual desire, cause bloating and gynecomastia.

Since Deca Durabolin is formulated using Nandrolone Decanoate, one of the longest esters in existence, it is very oil soluble, the way all steroids with long esters are. This easy solubility in oils means that manufacturers have to use a lower percentage of solvents to manufacture the products; thus, making for a less irritating shot. Generally, Deca injections are done weekly by most bodybuilders.

By adding 400mg per week of Nandrolone to a testosterone cycle or a Dianabol cycle, you'll be able to increase your overall steroid dosage, without increasing the side effects. For example, a bodybuilder taking 500mg Sustanon 250 per week, who felt he needed more power in his cycle, would find himself with more side-effects if he were to just take more of the same testosterone. Since testosterone aromatizes at an increasing rate at higher doses, there would be an exponential increase in the likeliness of gynecomastia and water retention if more testosterone was added weekly. When adding Nandrolone Decanoate to the same testosterone cycle, you are increasing the total amounts of steroids your body is receiving every week. However, you are not adding anymore viable substrate for undesired enzymatic reactions from aromatase and 5-reductase. In simple terms, you use more steroids without more side effects.

The dosage for men is around 400-600mgs per week but that varies depending on goals.
Side effects when stacking Deca Durabolin are a little different. As we all know, Deca is usually stacked with test and dbol. The problem is that testosterone and Dianabol are known to cause major side effects like water retention and the growth of breasts in men (gyno). These effects stem from these steroids being converted to estrogen (from testosterone) and 17a-methylestradiol (from Dianabol) by the aromatase enzyme. Other side effects these two steroids display are major hair loss and enlarging of the prostate, mainly due to testosterone's conversion to dihydrotestosterone via its inevitable interaction with the 5-reductase enzyme. Although Nandrolone has some limited interaction width both the aromatase and 5-reductase enzymes, the metabolites resulting from these interactions do not cause the same extreme side effects as test and dbol. Therefore, Deca Durabolin is basically a synergetic steroid that work well with all other bulking steroids. Allowing you to bulk more without more side-effects.

Thursday, January 29, 2015

Use of Anabolic Steroids in Patients Who Have HIV/AIDS

Of the 3 orally active anabolic steroids, Oxandrolone has been studied in HIV-infected patients more extensively than has Oxymetholone. Stanozolol is used for the treatment of hereditary angioedema and has not been used for its anabolic effect in this patient population to any great extent. Use of the steroid oxandrolone is associated with significant gains in weight and body cell mass in HIV-positive men who had experienced HIV-related wasting, according to an American study published in the March edition of the Journal of Acquired Immune Deficiency Syndromes. However, although the steroid increased muscle mass, it did not improve endurance and caused side-effects, including an increase in levels of ‘bad’ LDL cholesterol and elevations in liver enzymes. Unintentional loss of just 3% of body weight has been associated with poorer survival in HIV-positive individuals. Although the use of antiretroviral therapy has led to a significant decrease in the prevalence of unintended weight loss, it is still common, even amongst people taking HIV treatment.

One of the earlier studies of Oxandrolone in HIV-infected patients was begun before the introduction of the PIs. Sixty-three HIV-infected men with a loss of body weight greater than 10% were randomized to receive placebo; Oxandrolone, 5 mg/d or Oxandrolone, 15 mg/d. The patients who received 15 mg/d of oxandrolone gained weight throughout the 16-week period, whereas those who received 5 mg/d of Oxandrolone maintained their weight. In contrast, the patients who received placebo continued to lose weight.

In a follow-up study, which has not yet been published, patients were randomized to placebo or to 1 of 3 dosages of Oxandrolone - 20 mg/d, 40 mg/d or 80 mg/d (C. Grunfeld, unpublished data, 1998). The patients in the group who received 40 mg/d had the most statistically significant weight gain. However, both the patients in this group and those who received 80 mg/d showed significant increases in serum levels of liver transaminases.

A study published in 1999 sought to determine whether a regimen of supra physiologic doses of androgen (testosterone) plus an anabolic steroid (Oxandrolone) would improve the LBM and strength gains achieved with progressive resistance exercise in HIV-infected men who had experienced weight loss. A second objective of the study was to determine whether antiretroviral therapy with a PI prevented lean body anabolism.

All subjects in the study participated in supervised progressive resistance exercise for 8 weeks. At the same time, they received testosterone, 100 mg/wk, by intramuscular injection. Twenty-four eugonadal men were then randomized to either placebo or Oxandrolone, 20 mg/d. Twenty-two patients completed the study. The results indicated that compared with patients who received placebo, those who received Oxandrolone experienced improved nitrogen balance (P = .05); increased LBM (P = .005); and increased muscle strength, as judged by either maximum weight lifted (P = .02 to .05) or dynamometry (P = .01 to .05). The results were similar regardless of whether the patients were taking a PI. However, compared with placebo, Oxandrolone was associated with a statistically significant decrease in blood levels of high-den-sity lipoprotein (HDL) cholesterol (P < .001).

Because all patients in the study participated in progressive resistance training and received testosterone, only an additive effect of Oxandrolone versus placebo was being determined. Therefore, the study appears to be valid even though the number of patients enrolled was small. On the other hand, had the design of the study called for dividing the patients into multiple groups, so that not all patients received testosterone or participated in progressive resistance exercise, the number of patients required to reach statistical significance would have been much higher.

The conclusions that can be drawn from the study are that Oxandrolone  20 mg/d, added to a program consisting of both progressive resistance exercise and physiologic doses of testosterone improved the anabolic and functional responses in patients who showed HIV-related weight loss.

Only 1 study of Oxymetholone in HIV-infected patients has been reported. This study was a nonblinded pilot trial that was completed in Germany and reported in 1996. Patients were randomly assigned to receive either Oxymetholone (14 patients) or Oxymetholone plus ketotifen (16 patients). Ketotifen is an H1-receptor antagonist (ie, antihista- mine) that has been shown to block tumor necrosis factor a. The patients receiving the medications under study were compared with 30 matched control patients who met the same inclusion criteria, such as advanced HIV infection and chronic cachexia. On completion of the twelve-week double-blind phase of the study, all the patients were offered the option of remaining on the study for a further twelve weeks and receiving an open label 20mg Oxandrolone dose a day. By the end of this period, there were no differences in weight between patients and liver function ceased to be significantly different from baseline.

Although the investigators note that treatment with the steroid was generally “well tolerated” they note that over 5% of patients had moderate or severe increases in levels of liver enzymes and that “LDL levels decreased and HDL levels increased.”